Team Leader Yukawa gave a lecture at the 10th Ochanomizu Science Club held at the Sola City Conference Center.

Yukawa team members presented their research on nano quantum sensors at NanoTech2025 (in Tokyo Big Sight) held from 1/29 to 1/31.
nanotechexpo

A review of quantum life science has been published in Chemical Society Reviews, published by The Royal Society of Chemistry.
The article reviews the current state of quantum life science, covering topics such as research using bio-nano quantum sensors, hyperpolarized MRI/NMR, high-speed two-dimensional electron spectrometers, computer simulations, and more.

Yukawa H., Kono H., Ishiwata H., Igarashi R., Takakusagi Y., Arai S., Hirano Y., Suhara T., Baba Y. Quantum life science: biological nano quantum sensors, quantum technology-based hyperpolarized MRI/NMR, quantum biology, and quantum biotechnology, Chem. Soc. Rev. 2025; Jan 28. DOI: 10.1039/D4CS00650J

Team Leader Yukawa gave a lecture at the 12th Regular Meeting and the 12th Research Seminar of the Society of Functional Chemistry for Sustainable Society Development, FY 2024.

Team Leader Yukawa was invited to give a lecture at the 3rd Quantum Technology Seminar in Nagoya University.

Yukawa team's New Year's party was held.

Yukawa team held a year-end party.

The research of Senior Researcher Shimada has been selected for the Shimadzu Science and Technology Promotion Foundation's FY 2024 Research and Development Grant. We would like to extend our sincere congratulations.
Research Topic: Monitoring Single Cell Drug Response by On-Chip Imaging Measurement

Team Leader Yukawa gave an invited talk at the 12th Singapore International Chemistry Conference held in Singapore.
Title: Imaging of transplanted stem cells labeled with nano-quantum sensors
Home - SICC 12

The joint work of Team Leader Yukawa and Prof. Miki, Graduate School of Engineering, Kyoto University, has won the 14th CSJ Chemistry Festa 2024 Best Poster Presentation Award. Congratulations.
Title: Development of Hemicyanin Dyes for Specific Visualization of Cancer Stem Cells
○Yasuteru Miki, Yasutsugu Miki, Masahiro Asaue, Kaei Suzuki, Huiying Mu, Hiroshi Yukawa, Koichi Oe

Senior Researcher Agatsuma's paper has been published online. Congratulations.

Agetsuma M., Sato I, Tanaka Y.R, Carrillo-Reid L.Dissecting Neural Population Dynamics: Elastic Net and Conditional Random Fields for Deciphering Functional Networks and Information Processing in Learning and Memory, Neuromethods ("Identification, Characterization, and Manipulation of Neuronal Ensembles”) 2024; vol 215: C195 218. DOI: 10.1007/978-1-0716-4208-5_9

Senior Researcher Shimada's research has been selected for the Kao Health Science Research Foundation's 22nd Research Grant. Congratulations.
Research Topic: Creation of a Single Bacteria Analysis System Oriented to Prevention of Super Resistant Bacterial Infections

Team Leader Yukawa gave a lecture at the 3rd Lundbeck Phychiatry Academy held at Port City Takeshiba, Tokyo.
Content of Lecture: New Medical Possibilities with Quantum Technology in Psychiatry - A New Era of Mood Disorder Treatment: Possibilities of Nano-Quantum Sensors

Team Leader Yukawa gave a lecture at CMX WORKSHOP Emergence Conference in FY2024 held at Kobe University School of Medicine Shinryoku Memorial Hall.
Title: Advanced imaging diagnosis and treatment technology using nano quantum sensors
Center for Medical Transformation

Team Leader Yukawa gave an intensive lecture on Advanced Quantum Bioscience at Tohoku University Graduate School of Medicine.
Title of Lecture: Application of Nano-Quantum Sensors to Regenerative Medicine - Elucidation of the Mechanism of Regenerative Function of Stem Cells by Quantum Technology

Joint research by Dr. Ueda and Prof. Nishii et al. at Oyama National College of Technology on Cis-1,4-specific polymerization of 1,3-conjugated dienes with bis (benzimidazole) NiCl2 catalyst system has been accepted for publication in Polymer. Congratulations!

Ueda Y., Tsukahara K., Hasumi M., Uyama K., Yukawa H., Kato T., Toda T., Ohta S., Nishii K. Cis-1,4-specific polymerization of 1,3-conjugated dienes with bis (benzimidazole) NiCl2 catalyst system, Polymer 2024 in press.

Chief Researcher Agatsuma's research has been selected for the Takeda Science Foundation Life Science Research Grant 2024. Congratulations. (for 5 years until March 31, 2029)
Research Topic: Capturing and Regulating the “Hub” of Fear Memory Network in the Brain

The QI2024 Satellite Workshop : Dialogue between Quantum Life Science and Quantum Chemistry: A New Intersection of Knowledge for the Future was held at Ochanomizu Sola City. Senior Researcher Agatsuma gave a lecture with the following title.

Title: Dissecting deep brain neural networks involved in emotion and mental disorders: towards a deeper understanding through quantum life science

The results of the collaboration between Team Leader Yukawa, Prof. Asano and Prof. Suga, Graduate School of Medicine, Nagoya University, and Prof. Niioka, Data-Driven Innovation Initiative, Kyushu University, on a deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids have been accepted by Communications Biology. Congratulations.

Asano T., Suga H., Niioka H., Yukawa H., Sakakibara M., Taga S., Soen M., Miwata T., Sasaki H., Seki T., Hasegawa S., Murakami S., Abe M., Yasuda Y., Miyata T., Kobayashi T., Sugiyama M., Onoue T., Hagiwara D., Iwama S., Baba Y., Iwama S. A deep learning approach to predict differentiation outcomes in hypothalamic pituitary organoids. Commun. Biol. 2024 in press.

A Review paper on quantum life sciences, written by Team Leader Yukawa in collaboration with Deputy Director Suhara, Director General Baba, Deputy Director General Kono, Dr. Ishiwata, Group Leader Igarashi, Group Leader Takakusaki, Dr. Arai and Dr. Hirano, has been accepted for publication in Chemical Society Reviews. The paper has also been published in the RSC Fellows Celebratory Collection, which features papers that focus on particularly recent research trends. Congratulations.

Yukawa H., Kono H., Ishiwata H., Igarashi R., Takakusagi Y., Arai S., Hirano Y., Suhara T., Baba Y. Biological Nano Quantum Sensors, Quantum Technology-Based Hyperpolarized MRI/NMR, Quantum Biology, and Quantum Biotechnology. Chem. Soc. Rev. 2024 in press.

At the 19th In Vivo Imaging Forum 2024, Mr. Yamada, 3rd year PhD student, received Poster Award, and Ms. Handa, 2nd year MSc student of the Quantum Neuromapping and Neuromodulation Team, received the Best Poster Award. Congratulations.

Collaborative research on early cancer detection by multi-microRNA profiling of urinary exosomes with Prof. Yasui, Graduate School of Bioscience and Biotechnology, Institute of Science Tokyo, Prof. Yanagida, Graduate School of Engineering, University of Tokyo, Prof. Washio and Prof. Kawai, Institute of Scientific and Industrial Research, Osaka University, Prof. Ochiya, Institute of Medical Science, Tokyo Medical University. The results have been accepted by Analytical Chemistry. Congratulations.

Yasui T., Natsume A., Yanagida T., Nagashima K., Washio T., Ichikawa Y., Chattrairat K., Naganawa T., Iida M., Kitano Y., Aoki K., Mizunuma M., Shimada T., Takayama K., Ochiya T., Kawai T., Baba Y. Early Cancer Detection via Multi-microRNA Profiling of Urinary Exosomes Captured by Nanowires, Anal. Chem. 2024 in press. DOI: 10.1021/acs.analchem.4c02488

Team leader Yukawa gave a special lecture at the 18th Symposium on Medical Pharmaceutical Science for the Next Generation held at the Kanazawa Chamber of Commerce and Industry.
Lecture title: A new era of medical pharmaceutical science beckoned by nano-quantum sensor measurement technology

Mr. Shibata, a graduate student, and Ms. Handa and Ms. Takemoto, graduate students of the Quantum Neuromapping and Neuromodulation Team, received the 33rd Japan Bioimaging Society Scholarship Award at the 33rd Japan Bioimaging Society Annual Meeting. Congratulations to them.

Joint research results on 'Bacterial Raman spectral single-cell detection and linear discriminant analysis in glass filter micropores' with Dr. Onoshima, Institute of Nano-Life-System, Institutes of Innovation for Future Society, Nagoya University and AGC Corporation have been accepted for publication in Analytical Methods. Congratulations.

Onoshima D., Uchida K., Iida T., Kojima T., Ikeda Y., Iwata D., Nagasawa I., Yukawa H., Baba Y. Single-cell detection and linear discriminant analysis of bacterial Raman spectra in glass filter microholes, Anal. Methods 2024 in press.

Research results on 'Establishment of a stem cell administration imaging method in a mouse model of bleomycin-induced pulmonary fibrosis' with Ms. Suga, a master's student at the Nagoya University Graduate School of Engineering, Ms. Morita, a graduate, Dr. Iwatake, a cooperative researcher, and Dr. Sato, Nagoya University Graduate School of Medicine, were published in Organ Biology. Congratulations.

Authors: Suga S., Morita S., Iwatake M., Sato K., Baba Y., Yukawa H.
Title: Stem cell imaging diagnostic treatment for a mouse model of bleomycin pulmonary fibrosis
Journal: Organ Biology 2024; 31(2): 093-098.

A welcome dinner was held for new Yukawa team member.

Team leader Yukawa gave an invited lecture at the Vacuum Forum Symposium of the VACUUM 2024 Vacuum Exhibition at Tokyo Big Sight.
Lecture title: Development of state-of-the-art imaging diagnostic and therapeutic technologies based on quantum sensing and their medical and pharmaceutical applications

Team leader Yukawa gave an intensive lecture at the Graduate School of Frontier Sciences, Konan University.
Lecture name: Advanced Nanobio Drug Discovery

Team leader Yukawa gave an invited talk at the MACS Imaging and Spatial Biology - APAC User Group Meeting 2024 in Seoul, South Korea.
Title: Light-sheet microscopy imaging of transparent tissues and organs labelled with nano-quantum sensors

A commentary article by Team Leader Yukawa was published in the special feature 'Development of quantum life sciences into the medical field' in the weekly journal 'Igaku no Ayumi', Vol. 290, No. 4.

A commentary article on nano-quantum sensors, authored by Senior Researcher Agatsuma, postgraduate students Ms. Ito and Ms. Hatakeyama has been published in Precision Medicine. Congratulations.

Authors: Agetsuma M., Hatakeyama A., Ito C., Yukawa H.
Title: Development of advanced nano-quantum sensor technology for the development of regenerative and cellular medicine
Journal: Precision Medicine 2024 Aug Where we are now in medical information systems

Joint research results on 'Establishment of a stem cell administration imaging method in a mouse model of bleomycin-induced pulmonary fibrosis' with Ms. Morita, a graduate student of Nagoya University, Visiting Collaborative Researcher Iwatake, Prof. Sato, Nagoya University, Prof. Noguchi and Dr. Shiohira, University of the Ryukyu, have been accepted for publication in Scientific Reports. Congratulations.

Iwatake M., Morita S., Takahashi K., Sato K., Miyagi-Shiohira C., Noguchi H., Baba Y., Yukawa H. Establishment of a stem cell administration imaging method in bleomycin-induced pulmonary fibrosis mouse models, Sci. Rep. 2024 in press.

Senior Researcher Shimada's review paper on 'Application of fluorescent nanodiamond platforms for intracellular and on-chip biosensing' has been accepted for publication in Biosensors. Congratulations.

Shimada T., Ueda Y., Baba Y., Yukawa H. Advances of Fluorescent Nanodiamond Platforms for Intracellular and On-Chip Biosensing, Biodsensors 2024; 14(7): 340. DOI: 10.3390/bios14070340

Team Leader Yukawa gave an invited symposium lecture at the Kochi Chemistry Symposium 2024.
Title: Development of state-of-the-art imaging diagnostic and therapeutic technologies based on nano-quantum sensors and their medical and pharmaceutical applications.

Team Leader Yukawa gave a special lecture on career paths at Osaka Prefectural Ichioka High School.

The research of Senior Researcher Shimada has been selected for a 2024 research grant from the Murata Foundation for the Promotion of Science and Education. Congratulations.
Research topic: creation of a resistance analysis system based on electrical single-carbohydrate measurement.

The collaborative work of Team Leader Yukawa and Prof. Miki of Kyoto University on the development and biological application of probes for the detection of cancer stem cells has been accepted for publication in the Journal of Materials Chemistry B. Congratulations.

Miki K., Oe M., Suzuki K., Miki K., Mu H., Kato Y., Iwatake M., Yukawa H., Baba Y., Ueda Y., Mori Y., Ohe K. Dual-Responsive Near-Infrared Turn-On Fluorescent Probe for Cancer Stem Cell-Specific Visualization., J. Mater. Chem. B 2024 in press.

Yukawa team participated in the 6th Annual Meeting of the Quantum Life Science Society of Japan (Waseda University).

The 8th Q-LEAP Area Meeting was held at JST Tokyo Headquarters.

The results of joint research by Visiting Collaborative Researcher Iwatake, Prof. Nagamura (Univ. of Tokyo) and Prof. Tsuchiya (Univ. of Toyama) have been accepted for publication in Front. Immunol. Congratulations.

Iwatake M., Nagamura-Inoue T., Doi R., Tanoue Y., Ishii M., Yukawa H., Tsuchiya T. Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models. Front. Immunol. 2024; 15: 1384718. DOI: 10.3389/fimmu.2024.1384718

The joint work of Researcher Nishimura, Group Leader Osada, Team Leader Igarashi, and Researcher Kaminaga has been accepted by Langmuir. Congratulations.

Rikiyama K., Maehara N., Abe H., Nishimura Y., Yukawa H., Kaminaga K., Igarashi R., Osada K. Quantification of Poly(ethylene glycol) Crowding on Nanodiamonds toward Quantum Biosensor for Improved Prevention Effects on Protein Adsorption and Lung Accumulation. Langmuir 2024; 40(18): 9471-9480. DOI: 10.1021/acs.langmuir.3c03988

The 1st Innovative Bio Quantum Technology Research Meeting with Fujiwara Lab, Okayama University was held at Vacation Village, Omi Hachiman.

Team Leader Yukawa and Chief Researcher Agetsuma will be Special Editors of a special issue on quantum life science in the journal "Discover Nano".

For details, please check the following URL.
https://link.springer.com/collections/gjbiafbjeh

The call for paper submissions has already begun, and the deadline for submission is November 30 this year.
Interested team members are encouraged to contribute.

Team Leader Yukawa gave a special lecture at National Institute of Technology (KOSEN), Oyama College.
Title: Development of Advanced Imaging Diagnostic Techniques Using Nano-Quantum Sensors and Their Medical and Pharmaceutical Applications

Quantum Regenerative and Biomedicine Engineering Team New Year's Meeting
A lunch party was held for team members to welcome the new year.

The research of Senior Researcher Shimada has been selected for a single-year research grant in 2024 by the Ikeya Foundation for Science and Technology. Congratulations.
Research topic: development of an organelle temperature monitoring system using fluorescent nanodiamonds and microfluidics.

The research team's Web site is now available.